The research will focus on age-related macular degeneration (AMD), the most common cause of blindness in the developed world. In this research we will utilize comprehensive clinical information from electronic medical charts of thousands of patients, combined with analysis of retinal images, extensive characterization of the genome and the expression of protein of patients in order to obtain insights to AMD. The research will hopefully enable the identification of factors that are associated with specific phenotypes of AMD, as well as with the response to treatment in the neovascular stage of the disease. Such findings may significantly improve the understanding and treatment of AMD.