A Single-Cell-Based Approach to Study Transcriptomic Heterogeneity in Prenatal Clinical Samples from Congenital Human Cytomegalovirus (HCMV) Infections
Grant Amount: NIS 1.5 Million
About the Project
Human cytomegalovirus (HCMV) is the most common cause of congenital infection and neurodevelopmental disease worldwide, yet no reliable prenatal markers for disease have been identified. In this research project we will develop and employ a novel single-cell-based approach to uncover the unique responses of maternal and fetal cells to HCMV infection, within the authentic tissue complexity of the placenta and in clinical samples from natural congenital infections. We will correlate the observed patterns with congenital HCMV disease outcome, paving the way for prenatal prediction of the risk for congenital HCMV-induced defects in newborns.
Research Team
Prof. Yael Mandel-Gutfreund
Technion – Israel Institute of Technology, Biology
Prof. Dana Wolf
Hadassah Medical Center, Ein Kerem, Clinical Microbiology and Infectious Diseases
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