Characterization and Targeting of Cellular Senescence in Breast Tumors and their Microenvironment
Grant Amount: NIS 2.2 million
About the Project
During cancer development, cells often experience a variety of stresses, which can lead them to adopt a form of cell aging termed “senescence.” This study dissects how the presence of senescent cells in breast cancer influences disease progression, and tests whether drugs that specifically kill cells in this state can improve disease therapy. 
Research Team
Prof. Ittai Ben-Porath
Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, Hebrew University Faculty of Medicine
Prof. Amir Sonnenblick
Oncology, Sourasky Medical Center
Dr. Uri Ben-David
Human Molecular Genetics & Biochemistry, Tel Aviv University-Faculty of Medicine
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