Associating Stromal Cell Signatures with Structural Damage and Clinical Outcomes in Patients with Ulcerative Colitis
Grant Amount: NIS 2.8 million
About the Project
Ulcerative colitis is a chronic inflammatory disease of the large intestine that affects millions of people worldwide. The goal of this study is to explore how fibroblasts, the cells which build the connective tissue that provides structure to each organ, contribute to this inflammatory condition and to healing. This study will define signatures of tissue damage at the time of diagnosis of ulcerative colitis, and use these to predict disease complications over time.
Research Team
Dr. Dror Shouval
Institute of Gastroenterology, Hepatology and Liver Diseases, Schneider Children's Medical Center of Israel
Dr. Shalev Itzkovitz
Molecular Cell Biology Weizmann Institute of Science
Dr. Ruth Scherz-Shouval
Biomolecular Sciences, Weizmann Institute of Science
Dr. Henit Yanai
Gastroenterology, Rabin Medical Center
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